Reduce off-target capture by preventing adapter
xGen Blocking Oligos bind to adapter sequences to help prevent non-specific binding. Blocking the adapter sequences significantly improves capture performance. All xGen blocking oligos are compatible with any xGen Lockdown Panel or custom xGen Lockdown Probe set. Various blocking oligo options are available to accommodate different requirements and sequencing platforms. Choose from:
IDT recommends xGen Universal Blockers for Illumina TruSeq® and Nextera™ indexed libraries.